INSTITUTE OF BIOMEDICAL RESEARCH OF VLADIKAVKAZ SCIENTIFIC CENTER OF THE RUSSIAN ACADEMY OF SCIENCES AND THE GOVERNMENT OF THE REPUBLIC OF NORTH OSSETIA-ALANIA

 

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CHANGESBIOCHEMICAL MARKERSOF VASCULAR REMODELINGIN HYPERTENSION

 

DzuskaevaZ.O., YenaldievaR.V., AmbalovaS.A., AntoniadiI.V., AydarovaV.A.

 

To analyze the importance of identifying markers of endothelial dysfunction (nitrites and nitrates blood) and hypercholesterolemia in the early diagnosis of hypertensive disease (HD) is the aim of the study. 43 patients with hypertension of middle age 51,9±6,1 years with disease duration of 12.3±2.2 years and a control group of healthy persons (8 men, 13 women), comparable with the patients by sex, age and anthropometric data were examined. The level of nitrogen oxide was determined by enzyme immunoassay Griss ' reagent for the total content of nitrites and nitrates of blood. The level of nitric oxide in HD decreased significantly according to the increase of  blood pressure, which is evidence of the violation of vascular endothelial function. There is also a correlation between the increased level of blood pressure and the increase content of total cholesterol (TC), low density lipoproteids (LDL), however, reduce the level of nitrites outpaced lipid profile changes in patients with HD and it was revealed already in persons with high blood pressure. The study of nitric oxide is more highly informative diagnostic method of endothelial dysfunction and vascular remodeling in hypertensive patients in comparison with hypercholesterolemia, that may be used for early HD diagnosis.

 

Key words: endothelial dysfunction, nitric oxide, lipids.