INSTITUTE OF BIOMEDICAL RESEARCH OF VLADIKAVKAZ SCIENTIFIC CENTER OF THE RUSSIAN ACADEMY OF SCIENCES AND THE GOVERNMENT OF THE REPUBLIC OF NORTH OSSETIA-ALANIA
The effects of calcitonin on renal effects of ammonium molybdate Intragastric administration.
Brin V.B, Melikova E.R.
It is well known that ionized calcium levels may affect the metabolism of heavy metals in the organism. Investigation of the influence of calcitonin on the renal manifestations of ammonium molybdate intoxication on Wistar rats was carried out. Calcitonin was injected subcutaneously at a dose of 0.6 ED/100g within 20 days, and ammonium molybdate was administered intragastrically at a dose of 50 mg / kg for 20 days. It was found that ammonium molybdate induced polyuria due to the decrease in tubular reabsorption of water, despite the reduction in glomerular filtration rate, with marked proteinuria. Study of ion-excretory renal function (sodium, calcium and potassium) showed the increased excretion of electrolytes, which was a result of reducing of their tubular reabsorption and glomerular filtration rate. The research found that calcitonin hypocalcemia enhanced the toxic effect of ammonium molybdate.
Keywords: hypocalcemia, calcitonin, molybdenum, renal function.